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Vaccine against MPOX (Monkeypox)

What is MPOX?

Mpox (formerly monkeypox or monkeypox), is a viral disease caused by monkeypox virus (MPXV), a species of the genus Orthopoxvirus, first identified in humans in 1970 in the Democratic Republic of Congo.

The importance of prevention

Vaccination against smallpox, a disease caused by a related virus (thus not specific to monkeypox), provides some protection against monkeypox. Several studies have also shown that subjects previously immunized for smallpox (pre-1981) can achieve >85% coverage for monkeypox and consequently have less severe symptomatic manifestations.

The vaccine

Trade name:

Imvanex

Primary vaccination (individuals not previously vaccinated against smallpox):

A first dose of 0.5 mL should be administered at a specified date. A second dose of 0.5 mL should be administered no less than 28 days after the first dose.

Booster vaccination

(individuals previously vaccinated against smallpox): Inadequate data exist to determine the appropriate time for booster doses. If a booster dose is considered necessary, a single dose of 0.5 mL should be administered.I

Immunocompromised patients (e.g., patients with HIV infection, patients on immunosuppressive therapy)

he have already been vaccinated against smallpox should receive two booster doses. The second booster vaccination should be administered no less than 28 days after the first dose.

The vaccine consists of modified live Ankara vaccine virus

The vaccine is administered by subcutaneous injection, preferably in the arm (deltoid)

Contraindications Hypersensitivity to the active ingredient or any of the excipients ( trometamol, sodium chloride, water for injection preparations ) or to trace residues ( chicken protein, benzonase and gentamicin ). The most common side effects of Imvanex ( which may affect more than 1 in 10 people ) are headache, nausea, myalgia ( muscle pain ), fatigue, and injection site reactions ( pain, redness, swelling, induration, and itching sensation ).

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The information presented is general in nature, is published for general audiences and is not a substitute for the relationship between patient and physician.